I recently finished creating a portfolio website for a friend of mine using WordPress 3.0. Since the release of 3.0 I have found creating easy to mange websites a lot easier, especially since the new menu feature was added.
But my biggest issue with WordPress through its versions is its lack of customisation of the admin panel when you have it hand it over to an inexperienced user. Even when you setup someone up as a Editor they are still inundated with menus and functionality that they will never use.
This is where 3 must have plugins came to use, and allowed me to trailer the admin dashboard to my friends needs.